Polymorphic form of the compound 2 - (R) - (1 - (R) - (3,5-bis (tri - fluorometil) phenyl) ethoxy) - 3 - (s) - (4 - fluoro) phenyl 4 - (3 - (5 - oxo - 1H, 4H - 1,2,4 - triazolo) metilmorfolino,Process for the preparation of the form 1 of the same, pharmaceutical composition.The process to antagonise the effect of substance P on its place receptor or receptor blockade of the neurocinina - 1 in a mamu00ecfero, processes for treating or preventing a condition selected,The coffee - ground emesis, a disorder of the central nervous system, depression, anxiety, and schizophrenia in a mamu00ecfero, and product.

摘要

"Polymorphic form of the compound 2 - (R) - (1 - (R) - (3,5-bis (tri - fluorometil) phenyl) ethoxy) - 3 - (s) - (4) - fl uoro) phenyl) - 4 - (3 - (5) - oxo - 1H, 4H - 1,2,4 - triazolo metilmorfolino,)Process for the preparation of the form 1 of the same, pharmaceutical composition.The process to antagonise the effect of substance P on its place receptor or receptor blockade of the neurocinina - 1 in a mamu00ecfero, processes for treating or preventing a condition selected,The coffee - ground emesis, a disorder of the central nervous system, depression, anxiety, and schizophrenia in a mamu00ecfero, and.Product "this invention relates to a new polymorphic form of the compound 2 - (R) - (1 - (R) - (3,5-bis (trifluoromethyl) phenyl) ethoxy) - 3 - (s) - (4 - fluoro) phenyl) - 4 - (3 - (5) - oxo - 1H, 4H - 1,2,4 - Tr iazolo) metilmorfolino,It is an antagonist receptor of taquicinina useful in the treatment or prevention of central nervous system disorders, inflammatory diseases, pain or migraine, asthma and coffee - ground emesis.The polymorphic form this has advantages over other known forms of 2 - (R) - (1 - (R) - (3,5-bis (trifluoromethyl) phenyl) ethoxy) - 3 - (s) - (4 - fluoro) phenyl 4 - (3 - 5 (- oxo - 1H, 4H - 1.2.4 - triazolo) metilmorfolino, in terms of the thermodynamic stability and suitability for inclusion in pharmaceutical formulations.