Benzofuryl-alpha-pyrone derivative, pharmaceutical composition, lipid metabolism enhancer, triglyceride biosynthesis inhibitor, blood triglyceride reducing agent, blood hdl elevating agent, prophylactic agent for arteriosclerosis, and, treatment agent for arteriosclerosis

摘要

"BENZOFURIL-ALFA-PIRONA DERIVED, PHARMACEUTICAL COMPOSITION, LIPID METABOLISM ENHANCER, BIOSYSTEM INHIBITOR OF TRIGLYCERIDES, BLOOD TRIGLYCERIDES AGENT, BLOOD AGENT, TREATMENT AGENT ARTERIOSCLEROSIS ". Benzofuryl- 244 -pyrone derivatives represented by the general formula (I) or their salts in which R¹ represents hydrogen or C ~ 1-2 ~ alkyl; R² represents hydrogen, -CO-R ^ 5 ^ or SO ~ 2 ~ R ^ 6 ^; R ^ 3 ^ represents hydrogen, C ~ 1-5 ~ alkyl, etc .; and R4 is a substituent with a defined structure attached at the 4, 5, 6 or 7 position of the benzofuran ring. These compounds are useful as drugs for hyperglyceridemia, lipid metabolism-improving agents, preventives / drugs for arteriosclerosis, etc.