Proteins encoded by polynucleic acids from swine reproductive and respiratory syndrome viruses (prrsv)

摘要

Invention Patent: B "PROTEINS ENCODED BY POLYNUCLEIC ACIDS FROM REPRODUCTIVE AND RESPIRATORY PIG SYNDROME (PRRSV)" D. The present invention features a purified preparation that contains, for example, at least one polypeptide selected from the group consisting of proteins encoded by one or more open reading frames (ORFs) from an Iowa strain of pig reproductive and respiratory syndrome virus ( PRRSV), antigenic regions of these proteins that are at least five amino acids in length and that effectively protect a pig host against a subsequent challenge with a PRRSV isolate, and their combinations in which non-essential amino acids for antigenicity can be conservatively substituted . The present invention also relates to a vaccine that comprises an effective proportion of that protein; antibodies that specifically clump to that protein; methods for producing the same; and methods of protecting a pig from PRRSV, treating a pig infected with a PRRSV, and detecting PRRSV in a pig.