Mutant of equine herpesvu00ecrus sequence of nucleic acid, DNA molecule, recombinant, host cell, vaccine, and.Processes for the preparation of a mutant and genetically the EHV EHV to mitigate

摘要

"Herpesvu00ecrus mutant of equine, sequence of nucleic acid, DNA molecule, recombinant, host cell, vaccine, and.Processes for the preparation of a mutant of EHV and to mitigate genetically the EHV "this invention relates to new mutants of the herpesvirus equ00b3ino (EHV) comprising one or more deletions.Substitutions or insertions in the promoter region of the endogenous essential viral gene, preferably the immediately early gene EHV.Mutants of the EHV are stable and have reduced virulence, which makes it very suitable for use in a live vaccine.The invention also relates to live vaccines that comprise these mutants of EHV, sequ00b3u00eancias DNA and vectors that contain sequ00b3u00eancia of EHV transformed.The host cells transfected with said DNA or a vector. The invention also relates to a process for the mitigation of EHV in general and of EHV 1 in particular.