Compound, and, methods of inhibiting protein kinase activity, treating a patient who has a condition that is mediated by protein kinase activity and decreasing fertility in a patient

摘要

"COMPOUND, AND, METHODS OF INHIBITING PROTEIN KINASE ACTIVITY, TREATING A PATIENT THAT HAS A CONDITION THAT IS MEASURED BY PROTEIN KINASE ACTIVITY AND DECREASING FERTILITY IN A PATIENT". Chemical compounds that have structural formula (I) and their physiologically acceptable salts and metabolites, are inhibitors of serine / threonine and tyrosine kinase activity. Several of the kinases, whose activities are inhibited by these chemical compounds, are involved in immunological, hyperproliferative or angiogenic processes. Thus, these chemical compounds can improve disease states where angiogenesis or endothelial cell hyperproliferation is a factor. These compounds can be used to treat cancer and hyperproliferative disorders, rheumatoid arthritis, immune system disorders, transplant rejections and inflammatory disorders.