Amide derivative, process for preparing an amide derivative, or a pharmaceutically acceptable salt or cleavable ester in vivo thereof, pharmaceutical composition and use of an amide derivative, or a pharmaceutically acceptable salt or cleavable ester in vivo thereof

摘要

"STARCH DERIVATIVE, PROCESS TO PREPARE A STARCH DERIVATIVE, OR A PHARMACEUTICALLY ACCEPTABLE SALT OR IS CLIVABLE IN VIVO OF THE SAME, PHARMACEUTICAL COMPOSITION AND USE OF A STARCH DERIVATIVE, OR A PHARMACEUTICALLY AFFORDABLE SALT." The invention relates to amide derivatives of formula (I), wherein: G is N or CH; R¹ is a group such as hydroxy, halo, trifluoromethyl, C ~ 1-6 ~ alkyl and C ~ 1-6 ~ alkoxy; each of R² and R³ is hydrogen, halo, C ~ 1-6 ~ alkyl, C ~ 2-6 ~ alkenyl or C ~ 2-6 ~ alkynyl; R ^ 4 ^ is a group such as hydrogen, hydroxy, C ~ 1-6 ~ alkyl, C ~ 1-6 ~ alkoxy and C ~ 3-7 ~ cycloalkyl, or R ^ 4 ^ is of the formula (IC): - KJ, where J is aryl, heteroaryl or heterocyclyl and K is a bond or a group such as oxide and imino, R5 is a group such as hydrogen, halo and trifluoromethyl; m is 1 to 3 and q is 0 to 4; or their pharmaceutically acceptable in vivo cleavable salts or esters; to processes for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of diseases or medical conditions mediated by cytokines.