Method of inhibiting vascular hyperpermeability, and of inhibiting a physiological process or state in an individual

摘要

"METHOD OF INHIBITING VASCULAR HYPERPERMEABILITY, AND OF INHIBITING A PHYSIOLOGICAL PROCESS OR STATE IN AN INDIVIDUAL" Vascular hyperpermeability in individuals is a prelude to several physiological events that are often harmful. Among these events are the formation of edema, diapedesis, aberrant transendothelial change, extravasation, exudation and effusion, matrix deposition (often with abnormal stromal proliferation) and vascular hypotension. Vascular hyperpermeability and subsequent events can be inhibited by the administration of a compound that inhibits the activity of the VEGF tyrosine kinase receptor enzyme known as the KDR tyrosine kinase receptor. Preferred administered compounds selectively inhibit KDR tyrosine kinase function but do not block the Flt-1 tyrosine kinase activity which is another VEGF tyrosine kinase receptor.