Compounds derived from 5 - (Benzyloxy or Hydroxy phenyl) - 2 - 1 - Benzyl - 2,3 dihydro - 1H indole substituted, a Broker, their pharmaceutical compositions.As estrogen agonists / antagonists useful for treating or Preventing bone loss, states that are caused by lack of estrogen and cardiovascular diseases.

摘要

Compounds of formula: wherein R1 is H or benzyl; R2 is H or Oh - or benzyl; R3, R4 and R5 are selected independently from h, cyano, c1-c6 alkyl (straight chain or branched)Trifluoromethyl - or - C1, C12 Esters (straight chain, branched or cyclic) of these, halogen or Halogenated C1 - C6 ethers, R6 H or c1-c6 alkyl; R7 is C1 - C6 alkylN is 2 or 3; and is 0 or s; X: Where is the portion of ru00b4se Selects from C - C6 alkyl or lower portions: or,A Salt acceptable from the point of view of these as pharmacist; Pharmaceutical compositions useful for treating or Preventing diseases or syndromesWhich are caused by or related to a deficiency of estrogen or estrogen Excess and cardiovascular diseases.