Human Antibodies against IL - 12, which encodes a Nucleic Acid, Vector and host cell that Express them, Methods for their production, composition containing them,Useful for the treatment of diseases such as arthritis, Multiple Sclerosis and Crohn's disease.

摘要

Reveal Human Antibodies, preferably Recombinant human Antibodies, that specifically bind to interleukin-12 (Hil - 12).Preferred Antibodies have High affinity for Hil 12 and Neutralize the activity of Hil 12 in vitro and in vivo.An Antibody of the invention can be a full-length Antibody or an Antigen binding portion thereof.The Antibodies or Antibody portions, of the invention are useful for Detecting Hil 12 and to inhibit the activity of Hil 12That is a human being who is suffering from a disorder in which the activity of Hil 12 is harmful.Nucleic Acids, Vectors and host cells for expressing the Recombinant human Antibodies of the invention, and Methods for Synthesizing Human recombinant Antibodies.Also on included in the invention.