首页> 外国专利> 11beta - fluorine - 7alpha - (14,14,15,15,15 - pentafluoro - 6 - methyl - 10 - by thia - 6 - azapentadecyl) estra - 1,3,5 (10) - triene - 3,17beta - diol as a crystalline ansolvate

11beta - fluorine - 7alpha - (14,14,15,15,15 - pentafluoro - 6 - methyl - 10 - by thia - 6 - azapentadecyl) estra - 1,3,5 (10) - triene - 3,17beta - diol as a crystalline ansolvate

机译:11beta-氟-7alpha-(14,14,15,15,15-五氟-6-甲基-10-硫杂-6-氮杂十五烷基)雌二醇-1,3,5(10)-三烯-3,17beta-二醇作为结晶的溶剂化物

摘要

Describes the 11B - fluoro - (14,14,15,15,15 pentafluoro - 7 - 6 - methyl - 6 - 10 - Tia azapentadecil) - 1,3,5 estra - (10) - - - diolal Sledging 3,17b Crystalline State, in the form of its solvate.This is the estadoamorfo Waving Compound i in a Solvent or a Solvent mixture by crystallization or by displacement with Water Solution of the compound.To promote crystallisation can add Seed Crystals of the compound from a previous Production. The crystallization is accompanied by a purification.The Crystalline form of the compound I can be processed to obtain Pharmaceutical preparations as well as in the Amorphous form,Used for the treatment of estrogen dependent Diseases (Breast p.ej.carcinoma)
机译:描述11B-氟-(14,14,15,15,15五氟-7-6-甲基-6-10-硫杂氮杂十五烷)-1,3,5雌二醇-(10)---二醇类雪橇3,17b呈溶剂化物形式的结晶态,这是在溶剂或溶剂混合物中通过结晶或通过用化合物水溶液置换而形成的estadoamorfo挥舞性化合物i,为促进结晶,可添加先前生产的化合物的籽晶。结晶伴随纯化。化合物I的晶型可以加工得到药物制剂以及无定形形式,用于治疗雌激素依赖性疾病(乳腺癌)

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