Method for Preparation of compounds having a Ring structure and a steroidal sulfamate Group useful for inhibiting the activity of steroid sulfatase.

摘要

Compound comprising a ring sulphamate system and a group of the formula where each of the R1 and R2 is selected regardless of alquenil h, alkyl, aryl, and cicloalquil,Or alquileno together represent optionally containing one or more heteroatoms or groups in the Chain alquilena; and where the compound is an inhibitor of an enzyme's activitySteroid sulfatase (e.c.3.1.6.2); and where the Group sulphamate Compound on the outside to be replaced with a sulfate Group to form a compound and incubated with a sulfated steroid sulfatase Enzyme(e.c.3.1.6.2) at a pH of 744 and 37 degrees C. it could have a value of km of less than 50 um. Pharmaceutical Composition and its use to inhibit steroid sulfatase activity in a subject.