Adrenaline or its addition salt is prepared on industrial scale with asymmetric hydrogenation as the key step and special sequence of successive steps using a rhodium and bidentate phosphine ligand catalyst system

摘要

Preparation method of Adrenaline or a Salt by the addition of Adrenaline, where in the first stage adrenalone N - protected as reactant,Undergoes an Asymmetric hydrogenation in a Solvent with protico (RH (COD) cl 2) temperature and pressure controlled and a bidentate Chiral phosphine ligand and as catalizad SystemOr, later, in a Second Stage, The Adrenaline Rushes in basic conditions and resulting N - protected,In a Third Step separates the Protecting Group in conditions of acidity and temperature controlled.