Transdermal plaster containing at least one active substance affecting level of lipids in blood serum

摘要

In the present invention, there is disclosed a composition in the form of a transdermal therapeutic system, containing at least one active substance affecting level of fat in blood and being selected from the group consisting of active substances inhibiting hydroxymethyl glutaryl-coenzyme A reductase and at least one auxiliary substance promoting penetration of the active substance into a skin in a self-adhesive matrix layer, which can be covered on the side turned away from the skin with an active substance-impermeable backing layer, where the self-adhesive matrix layer is a substance based on polyacrylate or a substance based on silicon, and the auxiliary substance is selected from a group comprising pyrrolidone derivatives, fatty acids, fatty alcohols, fatty acids esters, fatty ethers, paraffin derivatives, terpenes, monoalkyl ethers of ethylene glycol, polyoxyethylene alkyl ethers, polyoxyethylene aryl ethers, polyoxyethylene alkyl esters, polyoxypropylene alkyl ethers, propylene glycol derivatives of fatty acids, glycerol esters of fatty acids, polysorbates, poloxamers, dialkyl sulfoxides, carbamide and carbamide derivatives, glycerol, native oils, laurocaprams, phospholipids, amides, amino acids, N,N-dimethylformamide, N-methyl formamide, acetonides, calcium thioglycolate, propylene glycol, polyethylene glycol, alkylsulfates, sodium lauryl sulfate, tetrahydrofurfuryl alcohol, macrocyclic compounds or polar solvents like panthenol.