COMPOSITION FOR PREVENTING CONTACT DERMATITIS CONTAINING BARRIER FILM AND METHOD FOR PREVENTING CONTACT DERMATITIS

摘要

1. A composition for preventing or reducing contact dermatitis which comprises: (1) a polysaccharide; (2) a low molecular weight, synergistic saccharide; (3) a solvent; and (4) optionally physiologically and psychologically favourable an additive agent. 2. The composition of claim 1 further comprises an antimicrobial agent wherein said polysaccharide is a cellulose derivative. 3. The composition of claim 1, wherein said polysaccharide is a cellulose derivative. 4. The composition of claim 3, wherein said cellulose derivative is selected from the group consisting of methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxybutylcellulose, methylhydroxyethylcellulose, methylhydroxypropylcellulose, methylhydroxybutylcellulose, hydroxyethylhydroxypropylcellulose, and ethylhydroxyethylcellulose. 5. The composition of claim 1, wherein said polysaccharide is hydroxypropylcellulose. 6. The composition of claim 1, wherein said low molecular weight, synergistic saccharide is selected from the group consisting of unmodified monosaccharide, derivatized monosaccharide, unmodified disaccharide, derivatized disaccharide, hydrolyzed starch, and derivatized starch hydrolysate. 7. The composition of claim 6, wherein said unmodified monosaccharide is selected from the group consisting of fructose, glucose, and mannose. 8. The composition of claim 6 wherein said unmodified disaccharide is selected from the group consisting of sucrose and maltose. 9. The composition of claim 6, wherein said derivatized monosaccharide is selected from the group consisting of ethoxylates of methyl glucoside, propox ylates of methyl glucoside, propoxylates of methyl glucoside distearate, and methyl glucose dioleate. 10. The composition of claim 6, wherein derivatized monosaccharide is about 20 mole ethoxylate of methyl glucoside. 11. The composition of claim 6, wherein said derivatized disaccharide is selected from the group consisting of about 10 mole ethoxylates, about 20 mole ethoxylates, about 10 mole propoxylates, and about 20 mole propoxylates. 12. The composition of claim 6, wherein said hydrolyzed starch is selected from the group consisting of maltodextrin and corn syrup solids. 13. The composition of claim 6, wherein said derivatized starch hydrolyate is selected from the group consisting of about 10 mole ethoxylates, about 20 mole ethoxylates, about 10 mole propoxylates, and about 20 mole propoxylates. 14. The composition of claim 1, wherein said solvent is selected from the group consisting of water, lower alcohols, low molecular weight glycols or mixtures thereof. 15. The composition of claim 1, wherein said additive agent is selected from the group consisting of colorants, fragrances, sunscreen, insect repellants , surfactants, flow modifiers, cleansers, moisturizers, film solubility modifiers, film plasticizers, salts, natural extracts, exfoliants, astringents, antioxidants, vitamins, self-tanning gents, emulsifiers, emollients, enzymes, keratolytics, antipruitics , analgesics, anesthetics, antihistamines, antimicrobial agents, preservatives, antibiotics, a ntiseptics, antifungals, antivirals, and mixtures thereof. 16. The composition of claim 1, wherein said polysaccharide is in the amount of about 5 wt.% to about 20 wt.%, wherein said low molecular weight, synergistic saccharide is in the amount of 2 wt.% to 10 wt.%, wherein said solvent is in the amount of about 70 wt.% to about 93 wt.%, and optionally wherein said additive agent is in the amount of about 0.01 wt.% to about of 30 wt.%. 17. The composition of claim 2, wherein said antimicrobial agent is selected from the group consisting of triclosan, hexetidine, chlorhexidine salts, 2-bromo-2-nitropropane-1,3-diol, hexyresorcinol, benzalkonium chloride, cetylpyridinium chloride, alkylbenzyldimethylammonium chlorides, iodine, phenol derivatives, povidone-iodine, parabens, hydantoins, hydantoins derivatives, phenoxyethanol, cis-isomer of 1-(3-chloroallyl)-3,5,6-triaza-1-azoniaadamantane chloride, diazolidinyl urea, benzethonium chloride, methylbenzethonium chloride, and mixtures thereof. 18. The composition of claim 2, wherein said antimicrobial agent is selected from the group consisting of triclosan, cis-isomer of 1-(3-chloroallyl)-3,5,6-triaza-1-azoniaadamantane chloride, hydantoins, hydantoin derivatives, and mixtures thereof. 19. The composition of claim 2, wherein said polysaccharide is in the amount of about 5 wt.% to about 20 wt.%, wherein said low molecular weight, synergistic saccharide is in the amount of 2 wt.% to 10 wt.%, wherein said antimicrobial agent is in the amount of about 0.1 wt.% to about 2 wt.%, wherein said solvent is in the amount of about 70 wt.% to about 93 wt.%, and optionally where in said additive is in the amount of about 0.01 wt.% to about of 30 wt.%. 20. A method for preventing or reducing contact dermatitis which comprises: applying a dermatologically-compatible barrier film composition to skin of mammals wherein said composition comprises (1) a polysaccharide; (2) a low molecular weight, synergistic saccharide; (3) a solvent; and (4) optionally an additive agent. 21. The method of claim 20, wherein said composition further comprises an antimicrobial agent. 22. The method of claim 20, wherein said polysaccharide is a cellulose derivative. 23. The method according to claim 22, wherein said cellulose is selected from the group consisting of methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxybutylcellulose, methylhydroxyethylcellulose, methylhydroxypropylcellulose, methylhydroxybutylcellulose, hydroxyethylhydroxypropylcellulose, and ethylhydroxyethylcellulose. 24. The method of claim 20, wherein said polysaccharide is hydroxypropylcellulose. 25. The method of claim 20, wherein said low molecular weight, synergistic saccharide is selected from the group consisting of unmodified monosaccharide, derivatized monosaccharide, unmodified disaccharide, derivatized disaccharide, hydrolyzed starch, and derivatized starch hydrolysate. 26. The method of claim 25, wherein said unmodified monosaccharide is selected from the group consisting of fructose, glucose, and mannose. 27. The method of claim 25, wherein said unmodified disaccharide is selected from the group consisting of sucrose and maltose. 28. The method of claim 25, wherein said derivatized monosaccharide is selected from the group consisting of ethoxylates of methyl glucoside, propoxyla tes of methyl glucoside, propoxylates of methyl glucoside distearate, and methyl glucos e dioleate. 29. The method of claim 25, wherein derivatized monosaccharide is about 20 mole ethoxylate of methyl glucoside. 30. The method of claim 25, wherein said derivatized disaccharide is selected from the group consisting of about 10 mole ethoxylates, about 20 mole ethoxylates, about 10 mole propoxylates, and about 20 mole propoxylates. 31. The method of claim 25, wherein said hydrolyzed starch is selected from the group consisting of maltodextrin and corn syrup solids. 32. The method of claim 25, wherein said derivatized starch hydrolysate is selected from the group consisting of about 10 mole ethoxylates, about 20 mole ethoxylates, about 10 mole propoxylates, and about 20 mole propoxylates. 33. The method of claim 20 wherein said solvent is selected from the group consisting of water, lower alcohols, low molecular weight glycols or mixtures thereof. 34. The composition of claim 20, wherein said additive agent is selected from the group consisting of colorants, fragrances, sunscreen, insect repellants , surfactants, flow modifiers, cleansers, moisturizers, water resistant compounds, salts, natural extracts, exfoliants, astringents, antioxidants, vitamins, self-tanning gents, emulsifiers, emollients, enzymes, keratolytics, antipruitics, analgesics, anesth etics, antihistamines, antimicrobial agents, preservatives, antibiotics, antiseptics, a ntifungals, antivirals, and mixtures thereof. 35. The method of claim 20, wherein said polysaccharide is in the amount of about 5 wt.% to about 20 wt.%, wherein said low molecular weight, synergistic saccharide is in the amount of about 2 wt.% to about 10 wt.%, wherein said solve nt is in the amount of about 70 wt.% to about 93 wt.%, and optionally wherein said additive agent is in the amount of about 0.01 wt.% to about of 30 wt.%. 36. The method of claim 21, wherein said antimicrobial agent is selected from the group consisting of triclosan, hexetidine, chlorhexidine salts, 2-bromo nitropropane-1,3-diol, hexyresorcinol, benzalkonium chloride, cetylpyridinium chloride, alkylbenzyldimethylammonium chlorides, iodine, phenol derivatives, povidone-iodine, parabens, hydantoins, hydantoins derivatives, phenoxyethanol, cis-isomer of 1-(3-chloroallyl)-3,5,6-triaza-1-azoniaadamantane chloride, diazolidinyl urea, benzethonium chloride, methylbenzethonium chloride, and mixtures thereof. 37. The method of claim 21, wherein said antimicrobial agent is selected from the group consisting of triclosan, cis-isomer of 1-(3-chloroallyl)-3,5,6-triaza-1-azoniaadamantane chloride, hydantoins, hydantoin derivatives, and mixtures there of. 38. The method of claim 22, wherein said polysaccharide is in the amount of about 5 wt.% to about 20 wt.%, wherein said low molecular weight, synergistic saccharide is in the amount of about 2 wt.% to about 10 wt.%, wherein said antimicrobial agent is in the amount of about 0.1 wt.% to about 2 wt.%, wherein said solvent is in the amount of about 70 wt.% to about 93 wt.%, and optionally where in said additive agent is in the amount of about 0.01 wt.% to about of 30 wt.%. 39. A dermatologically-compatible barrier film comprising: (1) a polysaccharide; (2) a low molecular weight, synergistic saccharide; and (3) optionally an additive agent. 40. The dermatologically-compatible barrier film of claim 39 further comprises an antimicrobial agent. 41. The dermatologically-compatible barrier film of claim 39, wherein sa