COMBINATION OF ACTIVE INGREDIENTS, IN PARTICULAR TETRAHYDROPYRIDINES AND AGENTS, INHIBITING ACETYL CHOLINESTERASE, FOR TREATING AN OLDGER TYPE BY ALTSHEIMER TYPE

摘要

The invention relates to a pharmacological composition containing as active ingredients a compound (a) selected from 1- (2-naphth-2-ylethyl) -4- (3-trifluoromethylphenyl) -1,2,3,6-tetrahydropyridine and the compound Formula (I) wherein Y is —CH— or —N—; R represents hydrogen, halogen, CF, (CC) alkyl or (CC) alkoxy; R represents hydrogen, halogen, hydroxyl, CF, (CC) alkyl or (CC) alkoxy; R and R are each hydrogen or (CC) alkyl; X is (a) (CC) alkyl; (C-C) alkoxy; (C-C) carboxyalkyl; (C-C) alkoxycarbonyl (C-C) alkyl; (C-C) carboxyalkoxy; or (CC) alkoxycarbonyl (CC) alkoxy; (b) a radical selected from (CC) cycloalkyl, (CC) cycloalkyloxy, (CC) cycloalkylmethyl, (CC) cycloalkylamino and cyclohexenyl, and the radical is optionally substituted by halogen, hydroxy, (CC ) alkoxy, carboxy, (CC) alkoxycarbonyl, amino, mono- or di- (CC) alkylamino; or (c) a group selected from phenyl, phenoxy, phenylamino, N- (CC) alkylphenylamino, phenylmethyl, phenylethyl, phenylcarbonyl, phenylthio, phenylsulfonyl, phenylsulfinyl or styryl, with the phenyl group possibly mono-or polysubstituted with a halogen, CF, CF, or steryl, phenylmethyl, phenylmethyl, phenylmethyl, phenylmethyl, phenylmethyl, phenylmethyl, phenylmethyl, phenylmethyl, phenylmethyl, phenylmethyl or phenylmethyl ) alkyl, (CC) alkoxy, cyano, amino, mono- or di- (CC) alkylamino, (CC) acylamino, carboxy, (CC) alkoxycarbonyl, aminocarbonyl, mono- or di- (CC) alkylaminocarbonyl, amino (CC) alkyl, hydroxy (CC) alkyl or halo (CC) alkyl, optionally in the form of one of its pharmaceutically acceptable salts, and - Compound (b) active in the symptomatic treatment of DTA, possibly in the form of one of its pharmaceutically acceptable salts, provided that when Compound (a) is different than 1- (2-naphth-2-yl-ethyl) -4- (3- trifluoromethylphenyl) -1,2,3,6-tetrahydropyridine or one of its pharmaceutically acceptable salts, then compound (b) is an inhibitor