CONFORMATIONALLY CONSTRAINED LH-RH ANALOGUES, THEIR USES AND PHARMACEUTICAL COMPOSITONS CONTAINING THEM

摘要

The invention relates to LH-RH peptide analogues with excellent affinity for LH-RH receptors, of the formula: V-W-X-SPL-Y-Pro-Z where V,W,X,Y and Z are as defined in the specification and SPL means spirolactam. The invention also relates to the uses of said peptide analogues and to the parmaceutical compositions containing them.