O-SUBSTITUTED HYDROXYCUMARANONE DERIVATIVES, THEIR USE FOR PRODUCING ANTITUMOR AND ANTIMETASTATIC MEDICAMENTS AND THE SAME MEDICAMENTS

摘要

Compounds of formula (I) wherein R and R 'are independently hydrogen, C 1-6 alkyl, styryl or C 3-6 cycloalkyl, or R and R' together with the carbon atom to which they are attached form C 3-6 cycloalkyl bridge; x is 0 or 1; A is - (CH2) n-, - (CH2) q-O- (CH2) q- or -CH2-A'-CH2- or C4-6 alkenylene; A 'is C 3-7 cycloalkyl; B is (i) -N (R1) - (CH2) m-N (R2) -, wherein m is 2-6; R1 is hydrogen, methyl, ethyl, propyl or isopropyl; and R 2 is C 1-6 alkyl, benzyl, phenyl, naphthyl or indanyl, which groups may have a substituent; or (ii) a group of formula (A), (B), (C), (D) or (E); T is -CH2-CCH, -CCH, - (CH2) p-R3, -CH = CH-R3, -CH2-NHCO-R3, - (CH2) pO-R3 or -CH (NH2) -CH2R3] (urokinase type plasminogen activator) antagonist activity and can be used as anti-tumor and / or anti-metastatic agents. SHE