N-ISOXAZOLYL-SULFONAMIDE DERIVATIVES, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND PROCESS FOR THEIR PREPARATION

摘要

The present invention relates to novel N-isoxazolylnaphthalenesulfonamide derivatives of formula (I) and their pharmaceutically acceptable salts, to pharmaceutical compositions containing them, and to the preparation of such compounds and pharmaceutical compositions. In the formula, one of X and Y is nitrogen and the other is oxygen; R 2 is halogen or hydroxy, carboxy, amino, C 1 -C 7 alkoxy, C 2 -C 7 alkenyl, C 1 -C 7 hydroxyalkyl, (C 1 -C 7 alkoxy) carbonyl, mono- or di- C 7 -C 7 alkylamino, mono- or di (C 1 -C 7 alkyl) amino (C 1 -C 7 alkyl), phenyl (C 1 -C 7 alkyl) amino, (C 1 -C 7 alkoxy) - carbonyl (C1 -C7 alkyl) amino, C1 -C7 alkanoylamino, phenyl (C1 -C7 alkyl) carbonylamino, [di (phenyl) (C1 -C7 alkyl)] -amino, (di (phenyl) - (C 1 -C 7) alkyl, carbonyl-amino, carboxy (C 1 -C 7) -alkylamino, 3-phenyl (thio-ureido) or optionally naphthyl optionally substituted by oxo-substituted, 5-7-membered saturated mono- nitrogen-containing heterocyclyl attached to its nitrogen atom, R4 and R5 are hydrogen, ornitro, phenyl, C1-7 alkyl, phenyl (C1-7 alkyl) or (1-7 hay alkoxy) carbonyl or R4 and R5 taken together form - (CH2) 4. The compounds of the formula I are endothelial antagonists and are useful inter alia for the treatment of hypertension. ŕ