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PROCESS FOR PRODUCING LOCALLY APPLICABLE PHARMACEUTICAL COMPOSITIONS COMPRISING ALLYLAMINE DERIVATIVE AGAINST FUNGUS INFECTION OF NAILS
PROCESS FOR PRODUCING LOCALLY APPLICABLE PHARMACEUTICAL COMPOSITIONS COMPRISING ALLYLAMINE DERIVATIVE AGAINST FUNGUS INFECTION OF NAILS
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机译:用于生产针对指甲真菌感染的包含烯丙胺衍生物的局部适用的药物组合物的方法
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摘要
FIELD OF THE INVENTION The present invention relates to pharmaceutical compositions containing a allylamine derivative of formula (I) in free base or in acid addition salt form, which are topically applicable to fungal nail diseases. In addition to the allylamine derivative, the compositions of the invention, such as nail polishes, include a film-forming polymer selected from the group consisting of polyvinyl acetate, copolymers of acrylic and methacrylic acid alkyl esters with quaternary ammonium radicals, and methyl vinyl ether. / maleic acid monoalkyl ester copolymerates and, if necessary, additional additives such as plasticizers, film modifiers, surfactants, penetration enhancers, colorants, antioxidants, complexing agents, UV absorbers, water and solvents. The compositions of the present invention have no systemic effect and the active ingredient contained therein is capable of penetrating deeper layers of nail tissue, i.e., fungi in the lower layers. ŕ
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