PURIFIED NONTYPABLE HAEMOPHILUS INFLUENZAE P5 PROTEIN AS A VACCINE FOR NONTYPABLE HAEMOPHILUS INFLUENZAE STRAIN

摘要

P5 outer membrane protein of nontypable Haemophilus influenzae bacterial strains which is substantially free of bacterial endotoxin, which is purified without the use of denaturing detergents or reducing agents and which elicits bactericidal antibodies, optionally conjuaged to an antigen of an organism or an epitope or epitopes of that antigen useful to reduce susceptibility to acute otitis media, sinusitis or chronic pulmonary obstructive disease.