13-SUBSTITUTED MILBEMYCIN 5-OXIME DERIVATIVES AND PESTICIDAL COMPOSITIONS CONTAINING THE SAME

摘要

Compounds of formula (I): CHEM in which: R1 is methyl, ethyl, isopropyl or sec-butyl; X is carbonyl or methylene; Z is =C=(R2)2 or =C=(CH2)m (in which R2 is alkyl, and m is integer of from 2 to 5); n is 0 or 1; R3 is nitro, amino, alkylamino, dialkylamino, alkoxy, alkoxyalkoxy, or a group (iii), (iv), (v), (vi), (vii), (viii) or (ix): CHEM CHEM CHEM CHEM (in which: R4 represents: alkyl; substituted alkyl; cycloalkyl having from 3 to 6 carbon atoms; substituted cycloalkyl; alkenyl; alkynyl; carbocyclic aryl; or heterocyclic; R5 is hydrogen atom or alkyl; R6 represents: hydrogen; alkyl; or cycloalkyl; R7 represents: alkyl; cycloalkyl; carbocyclic aryl; or aralkyl; or R6 and R7, together with the nitrogen atom to which they are attached, are fused to form heterocyclic ring; Y is oxygen or sulphur; r is 1, 2 or 3; Q is methylene or carbonyl; R8 is: alkyl or carbocyclic aryl; R9 is: alkyl; cycloalkyl; carbocyclic aryl ; or aralkyl; R10 is heterocyclic; and R11 is alkyl); have valuable acaricidal, insecticidal and anthelmintic activities.