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Methods of diagnosing clinical substypes of crohn's disease with characteristic responsiveness to anti-th1 cytokine therapy and a kit for diagnosing the same
Methods of diagnosing clinical substypes of crohn's disease with characteristic responsiveness to anti-th1 cytokine therapy and a kit for diagnosing the same
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机译:诊断对th1细胞因子疗法具有特征性反应的克罗恩病临床亚型的方法和诊断该试剂盒的试剂盒
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摘要
The present invention provides methods based on serological and genetic markers for diagnosing clinical subtypes of Crohn's disease (CD) having characteristic responsiveness to anti-Th1 cytokine therapy. In the methods of the invention, the presence of perinuclear anti-neutrophil antibody (pANCA), the presence of the TNFa10b4c1d3e3 haplotype or the presence of TNFa11b4c1d3e3 haplotype each is independently diagnostic of a clinical subtype of CD having an inferior clinical response to anti-Th1 cytokine therapy. In addition, the presence of the homozygous TNF-β 1111 haplotype involving the TNFc, aa13L, aa26 and NcoI loci is independently diagnostic of a clinical subtype of CD having an inferior clinical response to anti-Th1 cytokine therapy. The presence of speckling anti-pan polymorphonuclear antibody (SAPPA) is diagnostic of a clinical subtype of CD having a superior clinical response to anti-Th1 cytokine therapy.
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