LOOPED, HAIRPIN RIBOZYME

摘要

The invention provides a polyribonucleotide having a thermodynamically stable looped structure and a ribozyme activity, a DNA which codes for the same, and so forth. The polyribonucleotide is exemplified by the one with structure (b). When administered to the human body directly, the ribozyme polyribonucleotide can incise the target polyribonucleotide in vivo efficiently, thus being utilizable as a carcinostatic agent, anti-AIDS drug, and so forth. CHEM