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Use of a texaphyrin with a chemotherapeutic agent in cancer chemosensitization.
Use of a texaphyrin with a chemotherapeutic agent in cancer chemosensitization.
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机译:texaphyrin与化学治疗剂在癌症化学增敏中的用途。
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摘要
Use of texaphyrin with a chemotherapeutic agent in chemosensitization. The texaphyrin has the general Formula (II) wherein: M is a H, a divalent metal cation, or a trivalent metal cation; R1 -R4, R7 and R8 are independently hydrogen, halide, hydroxyl, alkyl, aryl, haloalkyl, nitro, formyl, acyl, hydroxyalkyl, alkoxy, hydroxyalkoxy, saccharide, carboxy, carboxyalkyl, carboxyamidealkyl, a site-directing molecule, or a couple that is coupled to a site-directing molecule; R6 and R9 are independently selected from the groups of R1 -R4, R7 and R8, with the proviso that the halide is other than iodide and the haloalkyl is other than iodoalkyl; R5 and R10 -R12 are independently hydrogen, alkyl, aryl, hydroxyalkyl, alkoxy, hydroxyalkoxy, carboxyalkyl, carboxyamidealkyl or a couple that is coupled to a saccharide or to a site-directing molecule; and n is an integer less than or equal to 5.
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机译:texaphyrin与化学治疗剂在化学增敏中的用途。特沙弗林具有通式(II),其中:M为H,二价金属阳离子或三价金属阳离子; R 1 -R 4,R 7和R 8独立地是氢,卤化物,羟基,烷基,芳基,卤代烷基,硝基,甲酰基,酰基,羟烷基,烷氧基,羟基烷氧基,糖,羧基,羧烷基,羧酰胺烷基,定点分子或一对与定点分子耦合; R6和R9独立地选自R1-R4,R7和R8,条件是卤化物不是碘化物,并且卤代烷基不是碘代烷基; R 5和R 10 -R 12独立地是氢,烷基,芳基,羟烷基,烷氧基,羟基烷氧基,羧基烷基,羧酰胺烷基或与糖或定点分子偶联的对; n是小于或等于5的整数。
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