The use of inhibitors of the sodium-hydrogen exchanger such as a benzoylguanidine in the production of a pharmaceutical for the treatment of diseases caused by protozoa

摘要

A Na+/H+ exchanger inhibitor is used in the manufacture of a medicament for the treatment or prophylaxis of disease caused by protozoa such as topical malaria. The Na+/H+ exchanger inhibitor is a substituted benzoyl guanidine, isoquinoline, benzoxazole, benzothiophene, indole, benzimidazole, benzothiazine, benzofuran, indenoyl guanidine, substituted diacylguanidine, isoquinoline acylguanidine, benzothiazine acylguanidine, fluoroalkyl substituted phenylalkyl carboxylic acid guanidide, furan guanidine, thiophene guanidine, pyrrole guanidine, bicyclic heteroaroyl guanidine, substituted phenylalkenyl carboxylic acid guanidide, benzyloxycarbonyl guanidine, fluorophenyl substituted alkenylcarboxylic acid guanidide, cinnamic acid guanidide, sulphonimidamide substituted benzoyl guanidine, biphenyldicarboxylic acid diguanidide, benzenedicarboxylic acid diguanidide, thiophenylalkenylcarboxylic acid guanidide, 1- or 2-naphthoyl guanidine, indanylidineacetyl guanidine, 6-membered N containing heterocyclic guanidine, indoloyl guanidine, guanidine, benzofuran guanidine, benzothiophene guanidine or indolyl guanidine derivative such as: 3-dimethylamino-5-trifluoromethylbenzoylguanidine, 3-phenyl-5-trifluoromethylbenzoylguanidine, 3-isopropyl-4-fluoro-5-trifluoromethylbenzoylguanidine, 3-chloro-5-(1-pyrrolyl)benzoylguanidine, 3-chloro-5-trifluoromethylbenzoylguanidine, 3-dimethylamino-5-(1-pyrrolyl)benzoylguanidine, 3-dimethylamino-4-tert-butylbenzoylguanidine, 4-(3-chloroanilino)-3-methylsulphonylbenzoylguanidine, 4-(4-aminoethylphenoxy)-3-methylsulphonylbenzoylguanidine, 4-(4-aminoethylsulphonylmethylphenoxy)-3-trifluoromethylbenzoylguanidine, 4-(4-aminoethylthiophenoxy)-3-trifluoromethylbenzoylguanidine, 3,5-di-tert-butylbenzoylguanidine, 3,5-di-tert-butyl-4-hydroxybenzoylguanidine, 5-chloro-2-indoloylguanidine, 3,5-dichloro-2-indoloylguanidine, 5-chloro-3-phenylthio-2-indoloylguanidine, 5-chloro-3-phenylsulphonyl-2-indoloylguanidine, 5-methoxy-3-isopropyl-2-indoloylguanidine, 4-benzyloxy-2-indoloylguanidine, 5-chloro-1-(4-picolyl)-2-indoloylguanidine, 2-(4-hydroxyphenyl)-4-benzimidazolylguanidine or N-{3-[3-(3-guanidino-2-methyl-3-oxopropenyl)phenyl]2-methylacryloyl}guanidine.