Water soluble polyether glycol polymer capable of complexing phosphate or oxalate used for reduction of dietary phosphate or oxalate absorption

摘要

A water-soluble polyether glycol polymer having: a structural backbone of carbon atoms and oxygen atoms where there are at least two consecutive carbon atoms present between each oxygen atom; derivatised with one or more primary or secondary polyamines, that is cationic at physiological pH and permits complexation with phosphate or oxalate. The polymer having an average molecular weight from 3,500 to 80,000 Daltons. The solubility of the polymer is at least 0.01 gram of the polymer per 1,000 ml of water. These polymers are formulated for oral dosage to reduce the phosphonate or oxalate levels in an animal. The process of preparing these polymers and the method of reducing gastrointestinal absorption of phosphate and oxalate are included.