A process for preparing a free-flowing form of paroxetine hydrochloride comprising spray drying solution of paroxetine hydrochloride in a spray drying apparatus to form paroxetine hydrochloride particles, under conditions selected to ensure that the particles are cooled sufficiently in the apparatus to prevent sticking. The process produces a paroxetine hydrochloride concentration between 5-20% suitable for the treatment of conditions such as alcoholism, anxiety, depression, obsessive-compulsive disorder, panic disorder, chronic pain, obesity, senile dementia, migraine, bulimia, anorexia, social phobia, pre-menstrual syndrome (PMS), adolescent depression, trichotillomania, dysthymia and substance abuse.
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