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Sustained analgesia achieved with buprenorphine via trans-dermal application
Sustained analgesia achieved with buprenorphine via trans-dermal application
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机译:丁丙诺啡经皮应用实现持续镇痛
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摘要
A method of effectively treating pain in humans is achieved by administering buprenorphine in accordance with first order kinetics over an initial three-day dosing interval, such that a maximum plasma concentration from about 20 pg/ml to about 1052 pg/ml is attained, and thereafter maintaining the administration of buprenorphine for at least an additional two-day dosing interval in accordance with substantially zero order kinetics, such that the patients experience analgesia throughout the at least two-day additional dosing interval.
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