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Composition comprising ciclesonide, propellant (1,1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoropropane or a mixture thereof) and ethanol
Composition comprising ciclesonide, propellant (1,1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoropropane or a mixture thereof) and ethanol
The pharmaceutical composition comprises a therapeutically effective amount of a compound of formula (I), in which: R1 is 1-butyl, 2-butyl, cyclohexyl or phenyl and R2 is acetyl or isobutanoyl, and a propellant selected from 1,1,1,2-tetrafluoroethane, 1,1,1,2,3,3,3-heptafluoropropane and a mixture thereof, and ethanol in an amount effective to solubilise the compound of formula (I) and optionally a surfactant. Also described is a pharmaceutical composition comprising the compound of formula (I), a hydrofluorocarbon propellant and a co-solvent in an amount effective to solubilise the compound of formula (I); in the form of an aerosol and contained in an aerosol canister equipped with a dispensing valve.
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