Compounds associated with melatoninergic system with basic ring structure of indole or naphthalene that show strong affinity for melatonin receptors and its subtypes

摘要

Substituted dimeric compounds of Formula (I) able to selectively interact with melatonin receptors thereby providing medicaments for the treatment of pathologies associated with melatoninergic system. Wherein; A represents formula -NR1C(Q)-R2-, -NR1C(Q)-NR2R3- or -c(Q)-NR2R3; wherein Q represents a sulphur or oxygen atom, R1, R2 and R3, which may be identical or different, represent a hydrogen atom or a group Ra (wherein Ra represents an unsubstituted or substituted linear or branched C1-6alkyl group, an unsubstituted or substituted linear or branched C2-6alkenyl group, an unsubstituted or substituted linear or branched C2-6alkynyl group, an unsubstituted or substituted C3-8cycloalkyl group, an unsubstituted or substituted cycloalkyl-C3-8alkyl-C1-6 group in which the alkyl moiety is linear or branched, a polyhaloC1-6alkyl group in which the alkyl moiety is linear or branched, an aryl group, an arylC1-6alkyl group in which the alkyl moiety is linear or branched, an arylC2-6alkenyl group in which the alkenyl moiety is linear or branched, a heteroaryl group, a heteroarylC1-6alkyl group in which the alkyl moiety is linear or branched or a heteroarylC2-6alkenyl group in which the alkenyl moiety is linear or branched, or the groupings R2 and R3 form, with the nitrogen atom carrying them, a group selected from piperazinyl, piperidinyl and pyrrolidinyl; B represents -NR1C(Q)R2-, -NR1C(Q)-NR2R3-, -C(Q)-NR2R3-, -C(Q)-OR1-, -NR1C(Q)-OR2- or -NR2R3; G1 and G3, which may be identical or different, represent a linear or branched alkylene chain having from 1 to 4 carbon atoms that is optionally substituted by one or more identical or different groups selected from hydroxy, carboxy, formyl, Ra, ORa, COORa and CORa; Cy represents a ring structure of Formula (II) or (III), wherein X and Y, which may be identical or different, represent sulphur, oxygen or carbon atom, or a CH or CH2 group, R4 represents a hydrogen or halogen atom, or a CF3, hydroxy, carboxy, formyl, amino, NHRa, NRaR1a, NHCORa, CONHRa, Ra, ORa, CORa or COORa group, Z represents a sulphur or oxygen atom, or a CH, CH2, NH, NSO2Ph or NRa group, D represents a benzene or pyridine ring; G2 represents a chain of Formula (IV); wherein W1, W2 and W3, which may be identical or different, represent a bond, oxygen or sulphur atom, or CH2, CHRa, NH or NRa group, n represents an integer wherein 0=n=6, m represents an integer wherein 0=m=6.