Combination of a 5HT1 receptor agonist, Caffeine, an inhibitor of Cox - 2 and its use for the treatment of migrana

摘要

Refers to a Pharmaceutical Combination comprising a 5HT1 receptor agonist eletriptan as sumatriptan, rizatriptan, zolmitriptan, naratriptan, using 0,05 mg / day to 100 mg / day; (b) using 15 mg / day Caffeine 200 mg / day; (c) an inhibitor of Cyclooxygenase 2 as (i) an indole Derivative of formula I, wherein R1 is H, c1-c4 alkyl; R2 is C (L = r3 `),So2r4; and is a Link, alquileno c1-c4; L and L 'are o, S; Q is c1-c6 alkyl, cycloalkyl C3 - C7 Aromatic phenyl, naphthyl, unicycle of 5-6 members; R3 is or6, nr7r8, N (OR1) R7,Group a; Z is o, S, a Link, NR5 alkyl; R4 is C1 - C6, among others; R5 is c1-c4 alkyl; R4 is c1-c4 alkyl, cycloalkyl C3 - C7, among others; R7 and R8 is C1 - C6 h, alkyl, cycloalkyl C3 - C7Among others; X is Halo, c1-c4 alkyl; n is 0 to 3; R is 1 - 3; ii) a compound XX, where a is a Five Member heterocycle, carbociclo 5 members; r1 is aryl,Heteroaryl alkyl; R2 is c1-4, R3, R4, R5 are h, Halo, c1-c4 alkyl; R6 and R7 are h, alkyl, Halo, among others, preferably 2 - Benzoyl - 6 - Chloro - 1H - 3 - yl) - acetic acid,Acid 6 - Chloro - 2 - (metilbenzoil) - 1H - 1H] indol-3-yl acetic, among others; using 10 mg / day to 300 mg / day. The combination may be useful in the treatment of migrana