Oral Pharmaceutical forms of Administration at least partially delayed Pharmaceutical tramadol whose active substance is at least partly in the form of a compound formed in situWater solubility less than or equal to 100mg / ml,.

摘要

Refers to an oral Pharmaceutical Form comprising Tramadol Hydrochloride), partially Retarded,Wherein the proportion is constituted by a delayed tramadol tramadol Compound formed in situ with water solubility u00be100mg / ml and found in excess; (b) other ExcipientActive substance and acid or acid salt such as sodium diclofenac, naproxen, ACETYLSALICYLIC ACID, Salicylic Acid, benzoic acid, cyclamateAcesulfame; because the equimolar ratio of constituents, because the release is the same vecocidad, because it presents as multiple particles, Granules, microparticles,Microtabletas or pellets; and has a Coating resistant to gastric Juice; such a formulation can be useful to fight Pain, urinary incontinence.It also relates to a process for Preparation, which is characterized by Wet several times with aqueous media with water or aqueous solutions and Binders are formulated with Input EnergyIn the form of pressure or heat