Composition comprising a polypeptide of interleukin 1 receptor antagonist and a diarilsulfonilurea as inhibitor of the processing and release of il-1

摘要

The invention relates to methods and compositions for treating and preventing interleukin 1 (IL-1) mediated disease states. The methods and compositions use an interleukin 1 receptor antagonist (IL-1ra) polypeptide or variant thereof in combination with a non-steroidal IL-1 processing and release inhibiting agent.