Pirrolicas substituted Mannich Bases with Analgesic activity

摘要

Refers to pirrolicas substituted Mannich Bases of formula I; r1 is H, C1 - C10 alkyl, aryl, heteroaryl; R2 is CH (R4) n (R5) (r6), R3, R3, R3 "H, F, CL, BR, CN, CF3, NO2, so2nh2, nhr7 SR8,,Or9, coor10, ch2coor11, cor15, among others; R4 is phenyl; R5 and R6 are c1-c6 alkyl; R5 and R6 form (CH2) n, (CH2) 2 (CH2) 2; n is 3 - 6; cor12 R7 is H, alkyl, aryl, C1 - C10Heteroaryl; R8 and R11 are C1 - C10 h, alkyl, aryl, heteroaryl; R9 is H, alkyl cor13, C1 - C10, among others; R12 is C1 - C10 alkyl, aryl, heteroaryl; R13 is C1 - C10 alkyl, aryl,Among others, R14 C1 - C10 is H, alkyl, aryl, heteroaryl; R15 is nhnh2, nhr14, C1 - C10 alkyl, aryl, among other Compounds, except when R1, R3,R3 'and R3 are h; R2 is CH (R4) n (R5) (r6) is phenyl; R4, R5 and R6 are CH3.Preferred compounds are 4 - [(2 - (4-methoxyphenyl) - 1H pyrrole 1 - phenyl - 2 - yl) methyl] - Morpholine, 4 - [[2 - (2-fluorophenyl) - 1H pyrrole il] - 2 - (2-methoxyphenyl) methyl] - Morpholine, among others.It also relates to a process for Preparation.Compound I can be useful for the treatment of Pain, inflammation, allergies, abuse of Drugs, alcohol, depression, diarrhea, gastritis, migrana, overweight, glaucoma