New crystal form of sodium n - 4 - 2 - 2-amine-4, 7-dihydro-4-oxo-3h-pirrolo 2, 3-d - pirimidin-5-il ethyl benzoate - L-glutamic and its processing program

摘要

It refers to a procedure for preparing a formula compound, which includes making pyrethrin [2,3-d] react at the position of formula 5 containing sodium hydroxide; R is a protective group of carboxi, such as methyl or ethyl ether. It also refers to N - [4 - [2 - (2-amino-4, 7-dihydro-4-oxo-3h-pirrolo [2, 3-d] pirimidin-5-i l] ethi] benzoil] - L-glutamic, which is characterized by X-ray derivative diagram. It also refers to a preparation procedure, including crystallization of discrete salts of a compound into an appropriate solvent,Adjust the pH value of the aqueous solution from 7.5 to 8.0. Glassy compounds are inhibitors of different enzymes that need to be used to treat Mesothelioma Cancer.