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Isoquinol and quinine derivatives with affinity to 5-HT1A, 5-HT1B, 5-HT1D mixed serotonin receptors
Isoquinol and quinine derivatives with affinity to 5-HT1A, 5-HT1B, 5-HT1D mixed serotonin receptors
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机译:对5-HT1A,5-HT1B,5-HT1D混合血清素受体具有亲和力的异喹啉和奎宁衍生物
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摘要
It refers to isoquinol and quinine derivatives containing R1 class I, II, P1-2, P3 and other substances, wherein R1 is class I and II; P1-2 and P3 are phenyl, northwest Africa class 5-6, benzene condensation heterocycle, and pyridine condensation heterocycle; RA, Rb, RC are halogen, C1-C6 tar, C3-C6, CF3, ALCOXY C1-C6, co2r5, NR6, etc.; R5 and R6 are R6; R5 and R6 are R6. C1-C6; N, P, q is 0-3; L is link, NH; R2 is h, or together with R3 Forman ch = ch, - (cr7cr8) 2 -;R7 and R8 are h, C1-C6 aspha R3 is h; X is n, ch; R4 is h, C1-C6 asphalt. 4-5) - methyl-methyl-4-methyl-methyl-methyl-1. Methyl pyridine-1-il pyridine (3,2-g) isoquinol, etc; He also mentioned a preparatory process 1. Compound I is an antidepressant with affinity to 5-HT1A, 5-HT1B and 5-HT1D butanediol receptors.
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