ANTINEOPLASTIC PHARMACEUTICAL PRODUCT FOR HUMAN AND VETERINARY USE, PREPARATION PROCESS THEREOF AND METHOD OF ANTINEOPLASTIC TREATMENT

摘要

The antineoplastic pharmaceutical product for human and veterinary use comprises 0.005 ... 5 % boric acid, 0.001 ... 4 % 2-dialkylaminoalkyl 4-aminobenzoate derivative of the general formula H2N - C 6 H 4 - CO- (CH 2) n - N(R) 2 as a base or salt, wherein the alkyl may be n-methyl, n-propyl, n-butyl, n-pentyl, n-hexyl, n-heptyl or n-octyl and up to 100 % distilled water or 0.9 % aqueous NaCl solution, the percents being expressed by weight. The process of preparing the antineoplastic product consists in disolving the boric acid and 2-dialkylaminoalkyl 4-aminobenzoate in distilled water or 0.9 % aqueous NaCl solution and heat treating for 5 ... 60 minutes at a temperature ranging from 50 to 150 degree C and a pressure of 0.5 ... 1.5 atm, the percents being expressed by weight. The method of antineoplastic treatment consists in administering a daily dose of 0.1 ... 10 mg/kg of body weight of antineoplastic pharmaceutical product divided in 1 ... 6 portions administered, orally, intramuscularly, intravenously or topically, in man or animals, at equal intervals, for 1 ... 24 months.