METHOD FOR PREPARING 4,10-DIACETOXY-2ALFA-BENZOYLOXY-5BETA,20- EPOXY-1,7BETA-DIHYDROXY-9-OXO-TAX-11-EN-13ALFA-YL (2R,3S)-3-BENZOYLAMINO-2-HYDROXY-3-PHENYLPROPIONATE TRIHYDRATE

摘要

Described is (2R, 3S) -4,10-diacetoxy-2alpha-benzoyloxy-5beta20-epoxy-1,7beta-dihydroxy-9-oxo-tax-11-en-13alpha-yl-3-benzoylamino-2-hydroxy trihydrate A process for the preparation of 3-phenylpropionate comprising (2R, 3S) -4,10-diacetoxy-2alpha-benzoyloxy-5beta, 20-epoxy-1,7beta-dihydroxy-9-oxo-tax- 11-en-13alpha-yl-3-benzoylamino-2-hydroxy-3-phenylpropionate is crystallized from a mixture of water and an aliphatic alcohol containing 1 to 3 carbon atoms, then the product obtained is dried under reduced pressure and then optionally maintained under conditions of relative humidity greater than 20%