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ENTERIC COATED PHARMACEUTICAL COMPOSITION, PHARMACEUTICAL COMPOSITION IN FORM OF SPHEROID BEADS, METHOD FOR MANUFACTURING PHARMACEUTICAL COMPOSITION
ENTERIC COATED PHARMACEUTICAL COMPOSITION, PHARMACEUTICAL COMPOSITION IN FORM OF SPHEROID BEADS, METHOD FOR MANUFACTURING PHARMACEUTICAL COMPOSITION
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机译:肠溶衣药物组合物,呈球状珠状的药物组合物,制造药物组合物的方法
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摘要
A high drug load enteric coated pharmaceutical composition is provided which includes a core comprised of a medicament which is sensitive to a low pH environment of less than 3, such as ddl, which composition is preferably in the form of beadlets having an enteric coating formed of methacrylic acid copolymer, plasticizer and an additional coat comprising an anti-adherent. The so-called beadlets have excellent resistance to disintegration at pH less than 3 but have excellent drug release properties at pH greater than 4.5. A novel method of making said pharmaceutical composition is also disclosed.
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