GABUNGAN-GABUNGAN YANG MENGANDUNG NILAI PENGOBATAN DARI MODULATOR-MODULATOR RESEPTOR ESTROGEN (SELEKTIF) (SERM) DAN SEKRETAGOGUE-SEKRETAGOGUE HORMON PERTUMBUHAN (GHS) UNTUK PENGOBATAN KELEMAHAN KERANGKA OTOT

摘要

This invention is directed to pharmaceutical combination compositions and methods containing (-)-cis-6-phenyl-5-(4-(2-pyrrolidin-1-yl-ethoxy)-phenyl)-5,6,7,8-tetrahydronaphthalene-2-ol or a pharmaceutically acceptable salt thereof and 2-amino-N-(2-(3a(R)-benzyl-2-methyl-3-oxo-2,3, 3a, 4,6,7-hexahydro-pyrazolo-[4,3-c]pyridin-5-yl)-1(R)-benzyloxymethyl-2-oxo-ethyl)-isobutyramide or a pharmaceutically acceptable salt thereof, methods of using such compositions and kits containing such compositions. The compositions are useful for treating musculoskeletal frailty, including osteoporosis, osteoporotic fracture, low bone mass, frailty and low muscle mass.