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blockeringsmedel

机译:封闭剂

摘要

On the surface of a cell there are different surface molecules, so called receptors. These receptors bind specific ligands, through which the cell becomes affected by its surroundings. Receptor molecules are also found on the surface of viruses and other pathogens. In contrast, such receptors are used for the attachment of the pathogen to a specific protein in the host and thereby for initiating the infection process. If membrane receptors of the cell are blocked, the cell will be prevented from being affected by a specific ligand, and if surface receptors of a pathogen are blocked, the pathogen will be prevented from being infectious. This invention relates to compounds, which will form very strong complexes with and thereby inhibit the biological function of for the compound specific surface structures (receptors) on cells, pathogenic microorganisms or viruses. The invention also relates to the design and preparation of such compounds for use as drugs or as tools for analytical or diagnostic purposes. The compounds comprise two or more identical protein domains interlinked by a peptide having such a length that each of the protein domains can interact simultaneously with its specific surface structure and thereby block the function of its structure. The protein domains might be human interleukin 2 (IL-2).
机译:在细胞表面存在不同的表面分子,即所谓的受体。这些受体结合特定的配体,细胞通过该配体受到周围环境的影响。受体分子还存在于病毒和其他病原体的表面。相反,此类受体用于病原体与宿主中特定蛋白质的附着,从而启动感染过程。如果细胞的膜受体被阻断,将防止细胞受到特定配体的影响,并且如果病原体的表面受体被阻断,则将防止病原体被感染。本发明涉及化合物,其将与细胞,病原性微生物或病毒上的化合物特异性表面结构(受体)形成非常强的复合物,从而抑制其生物学功能。本发明还涉及此类化合物的设计和制备,所述化合物用作药物或用作分析或诊断目的的工具。所述化合物包含两个或更多个相同的蛋白质结构域,所述结构域通过肽相互连接,所述肽的长度使得每个蛋白质结构域可同时与其特定的表面结构相互作用,从而阻断其结构功能。蛋白质结构域可能是人白介素2(IL-2)。

著录项

  • 公开/公告号SE0004782D0

    专利类型

  • 公开/公告日2000-12-22

    原文格式PDF

  • 申请/专利权人 ANN-CHRISTIN KOCH-SCHMIDT;

    申请/专利号SE20000004782

  • 发明设计人 ANN-CHRISTIN *KOCH-SCHMIDT;

    申请日2000-12-22

  • 分类号C12N;

  • 国家 SE

  • 入库时间 2022-08-22 01:23:25

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