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ANTIDEPRESSIVE 3-HALOPHENYLPIPERAZINYL PROPYL DERIVATIVES OF SUBSTITUTED TRIAZOLONES AND TRIAZOLDIONES
ANTIDEPRESSIVE 3-HALOPHENYLPIPERAZINYL PROPYL DERIVATIVES OF SUBSTITUTED TRIAZOLONES AND TRIAZOLDIONES
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机译:取代的三唑酮和三唑酮的抗抑郁药3-卤代苯并哌嗪基丙基衍生物
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Compounds of Formula I CHEM or a pharmaceutically acceptable acid addition salt and/or hydrate thereof wherein R is halogen and trifluoromethyl; X is oxygen and acetyl; the single and dotted lines represent either a covalent single or double bond; n is an integer from 2 to 4; and Z is hydrogen and CHEM in which R1 is hydrogen, halogen, C1-4 alkoxy and trifluoromethyl, which are psychotropic agents having promise as antidepressants by virtue of their receptor site binding affinity profiles and animal pharmacology.
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