Method for manufacturing activated inorganic products useful as solid supports for covalent immobilisation of lipases and other enzymes and new products thus obtained.

摘要

This invention relates to a new method of manufacturing activated for immobilization, by a covalent bond, lipases and other enzymes in which binding to the support surface takes place by formation of an imine bond between inorganic solids systems one aromatic aldehyde, previously attached to the surface of the inorganic support, and -NH groups {sub, 2} residual belonging to lysines of the protein. When employed as inorganic supports orthophosphate aluminum amorphous character, or gel fibrous silica obtained from sepiolite, high efficiency is achieved not only in the immobilization of the Lipase but that the latter, once immobilized, is Keep active. The process is expressed by the diagram where A = -0-; -OR- or - NH-R- and R can be, in principle, any alkyl group of character and / or aryl. **FORMULA 1**