HEPATITIS B VIRUS EPITHOPES INCLUDED IN THE RESPONSE OF CYTROXIC T-LYMPHOCYTES (CTL) RESTRICTED FOR HLA.

摘要

STIMULATING PEPTIDES OF CYTOTOXIC T-LYMPHOCYTE INDUCTING ANSWERS TO HEPATITIS B VIRUS ANTIGENS RESTRICTED TO HLA. THE PEPTIDES, DERIVED FROM THE EPITOPIC REGIONS OF THE CTL BOTH OF THE HBV SURFACE AND THE NUCLEOCAPSID ANTIGENS, ARE PARTICULARLY USEFUL IN THE TREATMENT AND PREVENTION OF THE INFECTION CAUSED BY THE HBV, INCLUDING THE TREATMENT OF CARRIERS OF HBV CARRIERS. PEPTIDES CAN BE FORMULATED AS VACCINES AND PHARMACEUTICAL COMPOSITIONS AGAINST HBV, SUCH AS COMPOSITIONS CONTAINING LIPIDS TO INTENSIFY THE CTL'S RESPONSES RESTRICTED TO HLA. PEPTIDES ARE ALSO USEFUL IN DIAGNOSTIC METHODS, SUCH AS THE PREDICTION THAT INDIVIDUALS INFECTED WITH HBV ARE PROPOSED TO DEVELOP A CHRONIC INFECTION.