OXIDIZED CAROTINOIDS, RETINOIDS AND RELATED CONJUGATED POLYNS, AND DERIVED FRACTIONS AND USEFUL COMPOUNDS AS CELLULAR DIFFERENTIATION INDUCTORS, CYTOSTATIC AGENTS AND ANTITUMOR AGENTS.

摘要

THE BE-CAROTENE, THE LICOPENO AND THE CATAXANTIN, AS REPRESENTATIVE CAROTENOIDS, AND IN A MINOR EXTENSION, THE RETINOIC ACID, A REPRESENTATIVE RETINOID, SUFFER AN EXTENSIVE OXIDATION TO RESULT AS CERTAIN SUBSTANCES, OR THE INSOCARE A MODEL, WHICH HAVE USEFUL PROPERTIES AS ACTIVE NON-TOXIC AGENTS AGAINST CELL PROLIFERATION, TUMORS AND TUMORIGENIC VIRUSES, AND ARE USEFUL AS PROMOTERS OF CELL DIFFERENTIATION. IT IS EVIDENT FROM A CHEMICAL ANALYSIS OF THE HIGHLY OXIDIZED CARBON MIXTURE THAT NO OF THE DIFFERENT FORMS OF VITAMIN ARE PRESENT OR ARE ONLY PRESENT IN MINOR AMOUNTS. IN ADDITION, THE BIOLOGICAL ACTIVITIES OF THE OXIDATED CATAXANTIN AND LICOPENO, WHICH CANNOT FORM VITAMIN A, INDICATE THE PRESENCE OF ACTIVE SUBSTANCES THAT ARE DIFFERENT FROM VITAMIN A. EVEN IF THE CYTOSTATIC AND PROMOTION ACTIVITIES OF THE DIFFERENTIATION THEY LOOK LIKE THOSE OF VITAMIN THEMSELVES, THEY ARE GENERALLY MORE POWERFUL FOR THE {BE} - CAROTENE IN A WIDE VARIETY OF CIRCUMSTANCES. DIFFERENT FROM VITAMIN A, THE {BE} -OXIDED CAROTENE OF THE INVENTION IS NOT TOXIC. OXIDIZED CAROTENOID IS A MIXTURE OF COMPOUNDS THAT CAN BE DIVIDED IN A NUMBER OF FRACTIONS ACCORDING TO WEIGHT AND MOLECULAR POLARITY. FRACTIONS EXHIBIT ANTICHANCERIGENE ACTIVITY COMPARABLE TO, OR GREATER THAN THE ACTIVITY OF THE OXIDATED CAROTENOID NOT FRACTIONATED.