COMBINATION BASED ON PYRIMIDINE DERIVATIVES AND CALCIUM ANTAGONISTS TO INDUCE AND STIMULATE HAIR GROWTH AND REDUCE HAIR LOSS

摘要

The invention relates to a combination of compounds intended to induce and stimulate hair growth and reduce hair loss. The combination according to the invention is characterized in that it comprises a component (A) containing in a physiologically acceptable medium, at least one calcium antagonist agent and a component (B) containing in a physiologically medium acceptable, at least one pyrimidine derivative corresponding to the formula: in which R1 denotes a group in which R3 and R4, independently of one another, denote a hydrogen atom or an alkyl, alkenyl, alkylaryl or cycloalkyl group , or R3 and R4 form, with the nitrogen atom to which they are linked, a heterocycle chosen from the group consisting of the aziridinyl, azetidinyl, pyrrolidinyl, piperidinyl, hexahydroazepinyl, heptamethyleneimine, octamethyleneimine, morpholine and alkyl- groups. 4 piperazidinyl, the heterocyclic groups being able to be substituted on the carbon atoms by one to three lower alkyl, hydroxy or alkoxy groups, and R2 denotes an a hydrogen or an alkyl, alkenyl, alkylalkoxy, cycloalkyl, aryl, alkylaryl, arylalkyl, alkylarylalkyl, alkoxyarylalkyl or haloarylalkyl group, or a physiologically acceptable acid addition salt thereof, the compounds sants (A) and (B) being present in a single composition or being intended for separate applications, either simultaneous, or successive or offset in time, on the scalp or on the hair.