PROCESS FOR PREPARING (BIS-(TRIFLUOROMETHYL)-PHENYL)-ACETIC ACIDS AND ALKYL ESTERS THEREOF AND DIALKYL (BIS-(TRIFLUOROMETHYL)-PHENYL)-MALONATES

摘要

[Bis-(trifluoromethyl)-phenyl]-acetic acids are obtained in an advantageousmannerby reacting an appropriate bromo- or iodo-bis-{trifluoromethyl)-benzene with adi-C1-C4-alkyl malonate in the presence of a deprotonating agent and a coppersalt andhydrolysing and decarboxylating the reaction product in basic medium. It ispossibleto obtain a mixture of alkyl [bis-(trifluoromethyl)-phenyl]-acetate and alkyl[bis-(tri-fluoromethyl)-phenyl]-malonate by admixing the reaction mixture which ispresentbefore hydrolysis and complete decarboxylation with water and acid andheating.From the mixture, it is possible to obtain alkyl [bis-(trifluoromethyl)-phenyl]-acetateby distillation under reduced pressure and dialkyl [bis-(trifluoromethyl)-phenyl]-malonate by work-up by column chromatography, fractional distillation or filmdistillation.[Bis-(trifluoromethyl)-phenyl]-malonic esters are novel compounds.