BENZIMIDAZOLES AND IMIDAZOPYRIDINES AS RESPIRATORY SYNCYTIAL VIRUS REPLICATION INHIBITORS

摘要

The present invention concerns compounds of formula (I), prodrugs, N-oxides,addition salts, quaternary amines, metal complexes and stereochemicallyisomeric forms thereof wherein -a1=a2-a3=a4- represents a radical of formula -CH=CH-CH=CH-; -N=CH-CH=CH-; -CH=N-CH=CH-; -CH=CH-N=CH-; -CH=CH-CH=N-; whereineach hydrogen atom may optionally be substituted; Q is a radical of formulae(b-1), (b-2), (b-3), (b-4), (b-5), (b-6), (b-7) and (b-8), wherein Alk is C1-6alkanediyl; Y1 is a bivalent radical of formula -NR2- or -CH(NR2R4)-; X1 isNR4, S, S(=O), S(=O)2, O, CH2, C(=O), CH(=CH2), CH(OH), CH(CH3), CH(OCH3),CH(SCH3), CH(NR5aR5b), CH2-NR4 or NR4-CH2; X2 is a direct bond, CH2, C(=O),NR4, C1-4alkyl-NR4, NR4-C1-4alkyl, t is 2 to 5; u is 1 to 5; v is 2 or 3; andwhereby each hydrogen in Alk and in (b-3), (b-4), (b-5), (b-6), (b-7) and (b-8), may optionally be replaced by R3; provided that when R3 is hydroxy or C1-6alkyloxy, then R3 cannot replace a hydrogen atom in the .alpha. positionrelative to a nitrogen atom; G is a direct bond or optionally substituted C1-10alkanediyl; R1 is an optionally substituted bicyclic heterocycle; R2 ishydrogen, formyl, C1-6alkylcarbonyl, Hetcarbonyl, pyrrolidinyl, piperidinyl,homopiperidinyl, C3-7cycloalkyl or C1-10alkyl substituted with N(R6)2 andoptionally with another substituent; R3 is hydrogen, hydroxy, C1-6alkyl, C1-6alkyloxy, arylC1-6alkyl or arylC1-6alkyloxy, R4 is hydrogen, C1-6alkyl orarylC1-6alkyl; R5a, R5b, R5c and R5d are hydrogen or C1-6alkyl; or R5a andR5b, or R5c and R5d taken together from a bivalent radical of formula -(CH2)s-wherein S is 4 or 5; R6 is hydrogen, C1-4alkyl, formyl, hydroxyC1-6alkyl, C1-6alkylcarbonyl or C1-6alkyloxycarbonyl; aryl is optionally substituted phenyl;Het is pyridyl, pyrimidinyl, pyryzinyl, pyridazinyl; as respiratory syncytialvirus replication inhibitors; their preparation, compositions containing themand their use as a medicine.