Method for the treatment and/or prophylaxis of diseases caused by il-12

摘要

A method for the treatment or prophylaxis of a disease caused by the production of IL-12, comprising administering to a subject in need thereof a compound selected from the group consisting of thalidomide, alpha-methyl thalidomide (EM 978), and 3-(1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione (EM 12), simultaneously with an anti-inflammatory cytokine in an amount effective for inhibiting IL-12 production. Also disclosed is a method for inhibiting IL-12 production in a cell that is capable of producing IL-12.