Antiangiogenic endostatin peptides, endostatin variants and methods of use

摘要

The invention provides an endostatin peptide having at least about 4-7 endostatin amino acid residues containing substantially the amino acid sequence of RLQD, RAD, DGK/R, or a functional equivalent thereof. The invention also provides an endostatin variant containing the amino acid sequence RGD, or a functional fragment thereof. Methods of inhibiting angiogenesis are also provided.